Inhibition of E-Selectin (GMI-1271) or E-selectin together with CXCR4 (GMI-1359) re-sensitizes multiple myeloma to therapy
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منابع مشابه
Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
BACKGROUND Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso-occlusion seen in sickle cell anemia, and selectin inhibition was able to restore blood flow in a mouse model of sickle cell disease. METHODS We perform...
متن کاملCorrection: Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia
Copyright: ß 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملSoluble E-selectin and P-Selectin Serum Levels in Patients with Psoriasis Compared to Healthy Controls
Introduction: Psoriasis is an inflammatory skin disease in which abnormal individual immune reactivity plays an important role. Eselectin and P-selectin are adhesion molecules expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. The aim of the present study was to describe selected immunological changes, concerning adhesion molecules status (sEsele...
متن کاملبررسی ژن e-selectin در سرطان پستان
سرطان پستان یکی از شایع ترین سرطان ها در میان زنان سراسر جهان است. این بیماری یک اختلال پلی ژنی پیچیده ای است که، عوامل ژنتیکی نقش مهمی درعلت بیماری بازی می کنند. e-selectin، همچنین به عنوان آنتی ژن cd62 مانند اعضای خانواده e (cd62e)، مولکول چسبنده اندوتلیال لوکوسیت1 (elam-1)، یا مولکول چسبنده لوکوسیت اندوتلیال2 (lecam2) شناخته شده است. مولکول چسبنده فقط در سلول های اندوتلیالی که توسط سایتوکاین...
GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice.
Leukocyte adhesion in the microvasculature influences blood rheology and plays a key role in vaso-occlusive manifestations of sickle cell disease. Notably, polymorphonuclear neutrophils (PMNs) can capture circulating sickle red blood cells (sRBCs) in inflamed venules, leading to critical reduction in blood flow and vaso-occlusion. Recent studies have suggested that E-selectin expression by endo...
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ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2019
ISSN: 2044-5385
DOI: 10.1038/s41408-019-0227-3